Application
Meclofenamic acid sodium salt has been used:in the inhibition of heat-induced denaturation of albuminas a pharmacological agent in the preparation of superfusion solution for electrophysiology studiesto block the gap junctions
Biochem/physiol Actions
Meclofenamic acid (MFA) is a nonsteroidal anti-inflammatory, analgesic and antipyretic drug. It inhibits prostaglandin biosynthesis pathway and finds its application in the treatment of postoperative and traumatic inflammation and swelling. MFA functions in opening the potassium voltage-gated channel subfamily Q member 2/member 3 (KCNQ2/Q3).
Cyclooxygenase (IC50 = 0.6 µM) and 5-lipoxygenase (IC50 = 46.3 µM) inhibitor.
Features and Benefits
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Meclofenamic acid consists of two aryl moieties that are twisted in perpendicular orientation, it includes N-2,6-dichloro-3-methylphenyl group and N-2-benzoic acid group. Because of the low aqueous solubility of the compound, it is commercially available as sodium salt.
Packaging
1, 5 g in glass bottle
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